Our goal is to understand the role of neural-immune interactions in pain, host defense, and immunity. It is increasingly clear that microbes and immune cells release mediators that impact the health and function of the nervous system. Neurons also release...
Autoimmune Disease Deconstruction:
We have implemented a disease deconstruction pipeline using single cell and spatial technologies applied to inflamed tissues in humans to discover new cell types, cell states and pathways that mediate autoimmune disease...
Our lab works in the broad fields of T cell differentiation, immunological tolerance, autoimmunity and inflammation, translating mechanistic studies on mouse models to normal and diseased humans. Studies on T cell differentiation focus on maturation and...
Our lab has several interests, generally organized around the genetic and genomic control of immunological tolerance and autoimmune diseases. We study how T cells differentiate into different lineages in the thymus, and how the Aire transcription factor...
The Pishesha Lab studies the biological complexities of antigen processing and presentation. We explore how these processes can be manipulated to modulate immunity. To that end we use engineered nanobodies and -for some applications- engineered red blood...
Antigen-Specific Basis of Autoimmunity and Cancer
The Kohlgruber lab investigates the antigen-specific basis of human diseases and applies high-throughput molecular, genetic, and immunological assays to decipher immune system specificities and...
A major focus of our studies has been the elucidation of genetic pathways regulating tolerance and to identify human diseases resulting from defects along those pathways. We have approached this issue from the perspective of Mendelian traits associated...
The major scientific interest of the Butovsky lab is to understand the biology of resident microglia and peripheral innate immunity in brain homeostasis and neurodegenerative conditions. The ultimate goal is to identify microglia- and monocyte-based...
The human intestine is exposed to a vast array of molecules from the microbiome, diet, and pathogens. The Nagashima lab focuses on three branches of research topics, all of which attempt to understand the gut immune system at the level of molecular...
Research in the Sage Lab focuses on understanding how the immune system regulates B cell responses and antibody production. Antibodies clear harmful pathogens and mediate protection elicited by vaccination. However, dysregulation of antibody responses can...
