Tissue immunoregulation in inflammation and cancer
Our lab studies the immune signaling pathways that support tissue integrity, and the mechanistic basis for tissue dysregulation in inflammatory disorders and cancer. The questions we pursue are grounded in understanding the interplay between tissue physiology and the innate immune system, as a central axis controlling homeostasis and disease. A major focus of the lab is the immunoregulatory roles of the non-immune cellular compartment comprising epithelial, vascular and stromal cells, in the development of pathological inflammation and cancer. We use advanced mouse models and imaging platforms, as well as a variety of genetic, molecular and cellular techniques to investigate immune signaling within tissues and to discover the factors that impact fundamental tissue functions in inflammation and cancer. Our mission is to identify effective therapeutic targets for restoring tissue integrity in immune-mediated disorders.
Building for Transformative Medicine, Room 9016AA
60 Fenwood Road
Boston, MA 02115