Assembly and signal transduction of the T cell receptor for antigen. To examine the role of the CD3 genes in thymocyte development and in T cell function we study mice in which the CD3 genes have been eliminated by homologous recombination techniques. In...
My research focuses on understanding the balance between protective antitumor immunity and immunotherapy toxicities. In preclinical mouse models my lab develops novel immunotherapies designed to reduce systemic toxicities. This has involved a variety of...
The Garrett Lab is interested in defining the dynamic interactions between the mucosal immune system and gut microbiota. Our experimental questions are grounded in understanding how interactions between intestinal microbial communities and the immune...
This laboratory's area of research involves studies of autoimmunity in models of experimental allergic encephalomyelitis, arthritis and diabetes in the NOD mouse. We are also investigating immune mechanisms in atherosclerosis, models of Alzheimer's...
Mast Cells are long-lived tissue resident immune cells that play a pathogenic role in human type 2 allergic inflammatory diseases. Mast cells arise from circulating progenitor cells that mature in peripheral tissues and take on different phenotypes based...
Scientists currently in my laboratory:
Dr. Claire Guinier - Postdoctoral fellow
Dr. Bruno Gonzalez - Postdoctoral Fellow
Mr. Hyshem Lancia – PHD student
Ms. Natacha Carnel – PHD student
Our laboratory is studying the role of different pathways of antigen...
My laboratory is interested in mechanisms and therapy of cancers. In the past years, I have been working on different types of hematologic and solid cancers. Most lymphomas, but also an increasing number of solid tumors, are characterized by defined...
Immunologists in the Winau Lab are most excited about the discovery of basic mechanisms that explain how the immune system functions. Over the years, we added to the passion for basic science a strong interest in identifying targets for possible...
Lipid signaling in immunity and inflammatory disease
My laboratory studies the biology of the bioactive lipid mediator- sphingosine 1-phosphate (S1P), a fundamental regulator of immune and vascular systems. The vertebrate immune system co-evolved with...
