Inflammation is a protective response to noxious stimuli that originate from infections and injured tissues. The inflammatory process triggered in response to microbial infections is instigated by pathogen-associated molecular patterns (PAMPs), while the...
The Cantor lab studies the development and function of T-cell subsets. Early studies indicated that the thymus gave rise to two major lineages of T cells that recognized the MHC class II and class I molecules and were equipped to mediate distinct...
Our current research focuses on: (i) understanding the relationship of Epstein-Barr virus (EBV) with cancer immunity and immunotherapy; (ii) developing and translating cytotoxic CD4+ T cell (CD4 CTL)-based therapeutic approaches for B cell malignancies...
Harness the tools and design principles of synthetic biology to develop novel therapies that can overcome key challenges in cancer immunotherapy
Cancer immunotherapy has shown tremendous success, however several major challenges such as the lack of ideal...
The Hacohen lab consists of immunologists, geneticists, biochemists, technologists, physicians and computational biologists working together to develop new and unbiased technologies and strategies to understand basic immune processes and immune-mediated...
Gut microbiota – the trillions of bacteria, fungi, viruses, and archaea that reside in our gut – contain a dynamic arsenal of products that can protect from or contribute to disease. Diet, medication, exercise, and disease impact the composition of the...
The overarching goal of the Jost lab is to define the molecular mechanisms of host-microbiome communication using a combination of systematic CRISPR technologies, physiological cell models such as organoids, and an interdisciplinary set of targeted...
Symbiotic microbiota residing on the body surface (gut lumen, skin and other areas) easily outnumbers our own cells and dwarfs our genome by hundred folds with their metagenome. Large-scale research projects such as Human Microbiome Project have...
Rapid advances in gene engineering make the previously unimaginable rapidly accessible. The Smith Lab for Genetic and Cellular Engineering uses synthetic biology to address our missions of: (1) answering pressing questions around the biology of...
My research focuses on understanding the balance between protective antitumor immunity and immunotherapy toxicities. In preclinical mouse models my lab develops novel immunotherapies designed to reduce systemic toxicities. This has involved a variety of...
