Assembly and signal transduction of the T cell receptor for antigen. To examine the role of the CD3 genes in thymocyte development and in T cell function we study mice in which the CD3 genes have been eliminated by homologous recombination techniques. In...
Immune cells play important roles in retinal vascular development/remodeling/repair and degeneration. Immune dysregulation during these processes in the eye leads to diseases such as retinopathy of prematurity and age-related macular degeneration. Our...
CD4+ T cell Tolerance
CD4+ T lymphocytes comprise a principal component of the adaptive immune system. These cells recognize processed antigens derived from foreign or self proteins and integrate this information with contextual signals from the innate...
The Early Life Development of the Immune System
The main focus of the Jain lab is to understand how immunity develops in early life. In utero, the developing fetal immune system must tolerate myriad maternal antigenic exposures including nutrients...
The Cantor lab studies the development and function of T-cell subsets. Early studies indicated that the thymus gave rise to two major lineages of T cells that recognized the MHC class II and class I molecules and were equipped to mediate distinct...
