Molecular Immunology

Our laboratory aims to understand the cellular and molecular interactions of the skeletal and immune systems in a relative recent branch of immunology termed osteoimmunology. Osteoimmunology studies the fundamental scientific principles that regulate the...

The Sen laboratory investigates the regulation of T cell dysfunction and explores epigenetic approaches for T cell engineering. We have found that the regulatory “circuitry” of dysfunctional T cells differs remarkably from functional T cells fighting off...

 

Influenza virus in humans evolves in response to pressure from immunity in the potentially susceptible population, resulting in progressive variation of viral antigenicity ("antigenic drift").  Introduction into human circulation of a new serotype from...

Symbiotic microbiota residing on the body surface (gut lumen, skin and other areas) easily outnumbers our own cells and dwarfs our genome by hundred folds with their metagenome.  Large-scale research projects such as Human Microbiome Project have...

The major goal of the Guerriero lab is to accelerate breast cancer immunotherapy by harnessing tumor associated macrophages. To date, immunotherapy has largely focused on recruiting and activating anti-tumor T cells, which has shown tremendous responses...

We seek to develop and apply technologies (particularly revolving around high-dimensional tissue imaging) to address questions related to host-disease interactions in their native tissue context. By combining these methodologies with a systems approach...

Research focus of my lab is to use novel synthetic biology approaches to manipulate conventional and memory-like Natural Killer (NK) cells to enhance their anti-tumor function. Using advanced CRISPR and non-CRISPR based gene editing approaches we are...

Our lab focuses on the molecular nature of innate immune interactions between microbial pathogens and the host. Pathogenic bacteria have evolved complex mechanisms to subvert host cell immune responses and host cell signaling pathways. Our work focuses...

Gut microbiota – the trillions of bacteria, fungi, viruses, and archaea that reside in our gut – contain a dynamic arsenal of products that can protect from or contribute to disease. Diet, medication, exercise, and disease impact the composition of the...

My laboratory studies pathomechanisms in wound healing and inflammation, utilizing human genetics, mouse genetics, and innovative OMICs technologies, as well as a broad array of functional assays. Our investigations are highly interdisciplinary and have...