Signal transduction in innate immunity
One of the major players in innate immune system is neutrophil which is the most abundant cell type among circulating white blood cells and constitutes the first line of host defense against invading bacteria and other pathogens. The long-term goal of our research is to elucidate the molecular mechanisms that control the number and function of neutrophil at the site of inflammation. We are also interested in the potential role of neutrophil in regulating bone marrow hematopoiesis and tumorigenesis.
Our research focuses on
1) signal pathways mediating neutrophil directional movement (chemotaxis).
2) molecular mechanism of neutrophil spontaneous cell death.
3) cell signaling in macrophage-mediated neutrophil clearance.
4) the potential role of neutrophils and acute inflammation in regulating bone marrow hematopoiesis
5) the role of neutrophils in tumor immunology
Currently, we are particularly interested in signaling pathways mediated by inositol phospholipid PtdIns(3,4,5)P3, inositol phosphates (e.g. InsP4 and InsP7), and reactive oxygen species (ROS). We utilize a wide variety of approaches ranging from basic molecular and cell biology methods to high throughput chemical genetic screening and animal inflammation models to dissect these pathways.
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