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We study the molecular pathways that regulate T cell function in the tumor microenvironment, with an emphasis on developing novel mechanistic insights that lead to the development of the next generation of cancer immunotherapies. We integrate analysis of...

The broad interest of the WAGERS LAB is to identify and analyze tissue-specific stem cell populations in adult animals. This work focuses on understanding the factors controlling the migration and expansion of bone marrow-derived and blood-forming...

We are interested in elucidating the mechanisms controlling immune privilege of tissue-resident stem cells and cancer stem cells.

Stem cells are crucial for tissue homeostasis and regeneration and, as a consequence, some have evolved mechanisms to cloak...

The Rao lab is focused on modulating pathologic lymphocyte functions to treat human autoimmune diseases. T cells are central regulators in multiple autoimmune diseases, yet defining their key functions in different diseases has been challenging. Our...

My laboratory focuses on the study of tissue resident T cells in humans. We isolate and study the T cells in human lung, cervix, decidua and gastrointestinal tract but we have a particular interest in T cells at home to and reside within the skin.

Our...

Research in the Sage Lab focuses on understanding how the immune system regulates B cell responses and antibody production. Antibodies clear harmful pathogens and mediate protection elicited by vaccination. However, dysregulation of antibody responses can...

In the Kuchroo laboratory, our overarching goal is elucidating the mechanisms that regulate immune functions in health, aging and different disease contexts. We focus on the functions of different CD4+ T helper subsets, and the role of costimulatory...